Pharm Final - MOA of drug classes 2 Flashcards


reduce the desire for physical activity


induce and maintain sleep


causes activation of the GABA receptor leading to hyperpolarization
of neurons - will cause sedation or sleep depending on dose


increases inhibitory activity of GABA - @ low dose it decreases
anxiety without drowsiness, @ high dose it induces sleep

Antidepressant Drugs

block reuptake of NE and serotonin stimulating CNS

Tricyclic Antidepressants (TCA's)

increases serotonin and NE but reserved for those who do not respond
to SSRI's

Monoamine Oxidase Inhibitor (MAOI's)

inhibits monoamine oxidase

Selective Serotonin Reuptake Inhibitors (SSRI's)

increases serotonin in synaptic cleft

Serotonin/Norepinephrine Reuptake Inhibitors (SNRI's)

increases serotonin and norepinephrine in synaptic cleft

Opioid Agonists

relieve or decrease pain without patient losing consciousness

Opioid Antagonists

used to reverse adverse drug reactions produced by agonists


decrease release of substance p (pain) in neurons and excitatory
neurotransmitter from nociceptors