BMB 401 Lecture 34 Flashcards

Nucleotidase

Nucleotide>nucleoside

Nucleoside phosphorylase

Nucleoside>free base & Ribose 1-P

Phosphoribomutase

Ribose 1-P>RIbose 5-P

Purine Catabolism Strategy

Convert to Xanthine
Eliminate as urate

Humans have high ___ and this is a potent___

Urate, antioxidant

Gout

Urate in high concentration can precipitate out as Na- rate crystals,
damaging joints and kidneys

SCID

Adenosine Deaminase Deficiency
Thymus is sensitive to this and does not produce immune functioning
t-cells like its supposed to
Affected are very immune compromised

A DNA

Right handed helix
short and broad
~11 bp/turn
DNA/RNA, RNA/RNA
Bases titles 19 deg

B DNA

MOST COMMON
Right handed helix
longer and thinner
~10 bp/turn
most DNA/DNA
bases slightly tilted

Z DNA

Left handed helix
long and thin
12 bp/turn
DNA/DNAgene regulation

Histone Transacetylase vs Histone Deacetylase

Transacetylase opens the RNA to increase transcription
Deacetylase closes to decrease transcription