Microbial Diseases of the Cardiovascular and Lymphatic systems Flashcards

Cardiovascular and Lymphatic Systems

Blood plasma leaves the blood capillaries to becomes interstitial fluid
Lymph capillaries: transport interstitial fluid to blood

Lymph nodes contain:

fixed macrophages
Bcells (Stimulated to produce plasma cells -> antibodies)
T cells


persistant pathogens or their toxins in the blood


Systemic inflammatory response (mediators are released into the
bloodstream, cytokines, microbe may not even be present in the blood)

Severe Sepsis

Sepsis and decreased blood pressure and dysfunction of one organ

Septic Shock

Sepsis and uncontrollable decrease in blood pressure


inflammed lymph vessels accompanying septicemia and septic shock

Gram-negative sepsis

Endotoxin shock
Endotoxins cause blood pressure to decrease
Antibiotics can worsen because kills bacteria, more endotoxin

Gram-positive sepsis

Nosocomial infections

Puerperal Sepsis

Childbirth fever
Streptococcus pyogenes
transmitted from mother to child during birth, physicians and midwives

Bacterial Infections of the Heart

Endocarditis, Subacute bacterial endocarditis, acute bacterial
endocarditis, pericarditis


inflammation of endocardium (inner layer of heart)

Subacute bacterial endocarditis

heart infection, develops slowly

Acute bacterial endocarditis

heart infection develops rapidly


inflammation of sac around the heart

Rheumatic Fever

inflammation of heart valves


Francisella tularensis - gram negative rod
transmitte from rabbits and deer by deer flies
Bacteria reproduce in phagocytes
lymph nodes enlarge


Undulant Fever
Brucella spp. Gram neg rods that grow in phagocytes
B. abortus - elk, bison, cows
B. melitensis - goats, sheep, and camels
fever spikes on evenings
Transmitted via milk from infected animals or contact with infected animals


Ischemia, necrosis, gangrene, gas gangrene


loss of blood supply to tissue


death of tissue


death of soft tissue

gas gangrene

clostridium perfringenes, bacteria that grows in necrotic tissue

Systemic diseases caused by bites and scratches

pasteurella multocida, clostridium, bacteroides, fusobacterium,
bartonella henselae (cat scratch disease)

Relapsing Fever

slow, Borrelia spp., spirochete (shape)
reservoirs are rodents
vectors are ticks
unlike undulant, this fever relapses slow, undulant up and down fast


Rickettsia spp.
obligate intracellular parasite
arthropod vectors

Epidemic typhus

Rickettsia prowazekii
pediculus humanus corporis - human body louse
louse feces are rubbed into bite wound

Spotted Fevers

Rocky Mountain Spotted Fever, Measles

Rocky mountain spotted fever

tickborne typhus, caused by rickettsia rickettsii
measle-like rash except rash appears on palms and soles

Burkitt's lymphoma

Epstein- Barr virus (HHV-4)
Cancer in immunosuppressed and in malaria and AIDS patients


caused by toxoplasma gondii
ingesting undercooked meat
contact with cat feces
congenital infection - still birth, neurological damage to fetus