IBS-C

which Rx drug is contraindicated in adults >65 and patients with a history of CV conditions?

tegaserod (Zalnorm)

class of tegaserod (Zelnorm)

5HT4 partial agonist

class of lubiprostone (Amitzia)

chloride channel activator

what is the SIG for lubiprostone (Amitiza) in normal population and hepatic dysfunction population?

- normal: 24 mcg PO BID- hepatic dysfunc: 8 mcg daily

indication for lubiprostone (Amitiza)

2nd line for IBS in women

which drug for IBS-C has a black box warning for children under 18?

linaclotide (Linzess)

which drug for IBS-C has a black box warning for children under 19?

plecanatide (Trulance)

what is the SIG for Linzess?

290 mcg PO daily at least 30 mis before first meal

what is the SIG for Trulance?

3 mg PO daily with or without food

what is the dosing for Miralax OTC?

17-35 g/day or BID (a full cap with an 8 oz water)

what are three SSRIs used to make small improvements in passage of stools in IBS-C?

#NAME?

which agent works by acting on the prostanoid activator of chloride channels (ClC-2)?

chloride channel activator - lubiprostone (Amitiza)

name two agents work by increasing the synthesis of cGMP to act on the cystic fibrosis transmembrane regulator (CFTR) to increase bowel motility?

#NAME?