Local anesthetic
blocks the increase in membrane permeability to Na during AP
nicotine
acts as an agonist for Ach; stimulant of skeletal and autonomic systems; 1 cigarette effects last ~1hr; in rat poison
venom of black widow spider
agonist that facilitates Ach release; dumping of Ach overexcites the muscles leading to spasms
Rohtpnol
depressant of the CNS; fast acting; mentally and physically
Insecticides
deactivation of Ach-esterase; potent Ach effect leads to muscle spasms